modern physical organic chemistry by eric v. anslyn, dennis a. dougherty pdf

'Determinants of nicotinic receptor gating in natural and unnatural side chain structures at the M2 9' position'. Proceedings of the National Academy of Sciences of the United States of America. 'From ab initio quantum mechanics to molecular neurobiology: A cation–π binding site in the nicotinic receptor'. 'Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine'. 'Unnatural amino acid mutagenesis in mapping ion channel function'. 'A fluorophore attached to nicotinic acetylcholine receptor βM2 detects productive binding of agonist to the αδ site'. 'A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors'. 'Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel' (PDF). 'In vivo incorporation of multiple unnatural amino acids through nonsense and frameshift suppression'. 'Establishing an ion pair interaction in the homomeric rho1 gamma-aminobutyric acid type a receptor that contributes to the gating pathway'. 'Physical organic chemistry on the brain' (PDF). 'Cys-loop neuroreceptors: structure to the rescue?'. Journal of the American Chemical Society.

'A stereochemical test of a proposed structural feature of the nicotinic acetylcholine receptor' (PDF). Main article: cation–pi interaction Selected publications In 2009, he was elected to the National Academy of Sciences.

Feynman Prize for Excellence in Teaching (2010). Anslyn.ĭougherty is the recipient of multiple teaching awards including the Richard Badger Teaching Award (1992), the ASCIT Excellence in Teaching Award (19), and the Richard P. In 2005 he published a textbook entitled Modern Physical Organic Chemistry with co-author Eric V. He is the scientific co-founder of Neurion Pharmaceuticals, Inc. In 1979 Dougherty became a member of the Caltech faculty, earning tenure in 1985.

in 1978 under the supervision of Kurt Mislow at Princeton University and was a post-doctoral scholar in Jerome Berson's lab at Yale University in 1979.

Modern physical organic chemistry by eric v. anslyn, dennis a. dougherty pdf